from Pittsburgh
Driving distance: 239.3 miles
Driving time: 4 hours
Driving distance: 239.3 miles
Driving time: 4 hours
| Mile | Instruction | For | Toward |
| 0.0 | Depart Pittsburgh on Elmore Sq (East) | 0.2 mi | |
| 0.2 | Bear RIGHT (West) onto Bentley Dr | 0.4 mi | |
| 0.7 | Turn RIGHT (South-East) onto Kirkpatrick St | 0.2 mi | |
| 0.9 | Turn RIGHT (West) onto 5th Ave | 0.1 mi | |
| 1.1 | Turn LEFT (South) onto Seneca St | 0.1 mi | |
| 1.2 | Turn LEFT (East) onto SR-885 [Boulevard of the Allies] | 0.1 mi | |
| 1.3 | Turn off onto Ramp | 0.3 mi | I-376 / Monroeville |
| 1.7 | Merge onto I-376 [US-22] (East) | 12.1 mi | |
| 13.8 | At US-22 Exit 18, turn off onto Ramp | 0.6 mi | I-76 / Pennsylvania Turnpike |
| 14.4 | *Toll road* Merge onto I-76 [Pennsylvania Tpke] (South) | 19.0 mi | |
| 33.4 | *Toll road* Continue (South-East) on I-70 [Pennsylvania Tpke] | 86.4 mi | |
| 119.7 | *Toll road* Continue (East) on I-76 [Pennsylvania Tpke] | 81.2 mi | |
| 200.9 | At I-76 Exit 18, turn off onto Ramp | 0.6 mi | |
| 201.5 | Merge onto I-83 (South-East) | 17.7 mi | |
| 219.2 | At I-83 Exit 9, turn off onto Ramp | 0.1 mi | |
| 219.3 | Turn LEFT (East) onto US-30 [Arsenal Rd] | 19.1 mi | |
| 238.4 | At US-30 Centerville Rd Exit, bear RIGHT (East) onto Ramp | 0.1 mi | |
| 238.6 | Turn LEFT (South-East) onto Centerville Rd | 109 yds | |
| 238.6 | Turn RIGHT (West) onto Hempland Rd | 0.7 mi | |
| 239.3 | Arrive 3549 Hempland Rd, Lancaster, PA 17601 | ||
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